Ascorbic acid coadministration with artesunate–amodiaquine, up-regulated antioxidant enzymes gene expression in bone marrow cells and elicited biochemical changes in Plasmodium berghei-infected mice

Abstract One of the hallmarks malaria infection is oxidative stress. This study was aimed at investigating potential effects coadministering a therapeutic dose artesunate–amodiaquine (AS/AQ) with Vitamin C (Vit C) orally on some biochemical parameters and antioxidant enzymes gene expression in bone marrow cells Plasmodium berghei -infected mice. Thirty male Swiss albino mice were divided into five groups six each as follows: Basal control (not infected P. ), Untreated ( without treatment), Vit C, AS/AQ + combination treated Treatment done twice daily for three consecutive days. Complete parasite clearance observed second day treatment Serum albumin bilirubin levels higher compared those only. Artesunate–amodiaquine increased superoxide dismutase activity reduced hydrogen peroxide malondialdehyde when only AS/AQ. Furthermore, significantly up-regulated catalase glutathione peroxidase-1 (GPx-1) mRNA first report linking to enzyme cells. Our findings showed that coadministration may be beneficial it ameliorated stress